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. Author manuscript; available in PMC: 2016 Dec 3.
Published in final edited form as: Neuroscience. 2015 Sep 9;310:12–26. doi: 10.1016/j.neuroscience.2015.09.018

Figure 6.

Figure 6

Effect of the D1 receptor agonist SKF81297 (SKF) on mRNA transcription of the immediate-early genes c-Fos and ARC within the primary motor cortex (M1; n = 6–7 per group). Rats received a unilateral lesion with 6-hydroxydopamine. (A) After surgical recovery, rats were given a total of three injections of the D1 agonist SKF81297 (SKF) or Veh over a 7 d period (“Sessions 1–3”). Two days later (“Session 4”), rats were given SKF or Veh and rated for AIMs for 120 min. Rats received the same treatment on all four sessions, except the “Lesion - Veh (SKF Primed)” group, which received SKF on sessions 1–3 and Veh on session 4. Data points show total AIMs scores for individual rats, while the horizontal line indicates the median score. Two hours after session 4 injections, all rats were decapitated and M1 tissue was analyzed via real-time polymerase chain reaction. Hemispheres are denoted as either ipsilateral or contralateral (to lesion). Percent change in mRNA was normalized to control (“Lesion - Veh [contralateral]”). (B) c-Fos mRNA. (C) ARC mRNA. § p < .05 vs. Session 1; * p < .05 vs. Lesion - Veh (ipsilateral); + p < .05 vs. Lesion - Veh (contralateral); # p < .05 vs. own contralateral hemisphere.