Table 3.
Association of lead SNPs identified in women of European and non-European descent with breast cancer risk among women of Asian (6,269 cases and 6,624 controls) and African ancestry (1,116 cases and 932 controls).
| Top SNPs | Allelesb | Single Marker Analysis (Asian) | Single Marker Analysis (African) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RAF | LD (r2)c | OR (95% CI) d | P trendd | RAF | LD (r2)c | OR (95% CI) d | P trendd | |||
| Identified in women of European descent | ||||||||||
| Signal 1 | rs9790517a | T/C | 0.60 | - | 1.00(0.95–1.06) | 0.93 | 0.06 | - | 1.21(0.88–1.55) | 0.28 |
| Signal 2 | rs77928427 | A/C | 0.06 | 0.01 | 1.02(0.91–1.12) | 0.50 | 0.16 | 0 | 1.03(0.85–1.22) | 0.86 |
| Identified in women of non-European descent | ||||||||||
| rs1116764 | G/A | 0.66 | 0.13 | 1.10(1.04–1.16) | 4.21×10−4 | 0.89 | 0 | 1.02(0.81–1.23) | 0.98 | |
| rs79219151 | C/T | NA | 0.95 | 0 | 1.63(1.13–2.13) | 7.44×10−3 | ||||
| rs112095278 | C/T | NA | 0.95 | 0 | 1.65(1.16–2.14) | 4.13×10−3 | ||||
| rs144956461 | A/T | NA | 0.93 | 0 | 1.56(1.12–2.01) | 6.73×10−3 | ||||
Abbreviations: OR, odds ratio; CI, confidence interval; RAF, risk allele frequency.
a
Index SNP
b
Risk/reference allele; risk alleles are shown in bold.
c
r2 for linkage disequilibrium with the index SNP rs9790517 in Asians and Africans, respectively.
d
Adjusted for age, study and the first six PC and an additional PC for LMBC study.