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. Author manuscript; available in PMC: 2016 Dec 3.
Published in final edited form as: Neuroscience. 2015 Sep 28;310:401–409. doi: 10.1016/j.neuroscience.2015.09.048

Figure 4.

Figure 4

The GABAA current equilibrium potential in human sensory neurons is depolarized relative to normal resting membrane potentials. A. A ramp protocol was used to determine the equilibrium potential for the GABA evoked currents. A step-and ramp voltage clamp protocol (bottom trace) was used to evoke current in the presence (gray trace) and absence (black trace) of GABA (applied half way through the step to −30 mV). B. The difference current was plotted relative to the ramp voltage, and the point of 0 current was considered the equilibrium potential. The mean (± SEM) of the equilibrium potential determined from 6 neurons from two different donors is indicated.