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. Author manuscript; available in PMC: 2016 Dec 3.
Published in final edited form as: Neuroscience. 2015 Sep 21;310:206–215. doi: 10.1016/j.neuroscience.2015.09.042

FIGURE 2.

FIGURE 2

NMDA-induced acute masseter hypersensitivity involves TRPA1. (A) Line graph shows changes in masseter mechanical thresholds induced by NMDA in the presence of the TRPA1 antagonist, AP18 (n=6 per group). (B) Bar graph shows the overall magnitude of drug effect as measured by area under curve. (C) Overall effects of HC-030031 during the same time course are shown as area under curve (n=4 per group). BL: baseline 15 min prior to NMDA injection. Arrow: vehicle or antagonist injection 5 min prior to αβmeATP injection. +, * indicates significant (p<0.05) group and time effects, respectively.