Table 1.
Demographics and clinical characteristics.
| Variable | Overall N=175 | Buspirone N=88 | Placebo N=87 | P Value |
|---|---|---|---|---|
| Demographics and Clinical | ||||
| Characteristics | ||||
| Age | 24.0 (23.1-25.0) | 24.0 (22.7-25.3) | 24.0 (22.6-25.4) | 0.717 |
| Male | 76.6 (134) | 76.1 (67) | 77.0 (67) | 0.891 |
| Caucasian | 64.0 (112) | 65.9 (58) | 62.1 (54) | 0.597 |
| HS Graduate | 90.3 (158) | 89.8 (79) | 90.8 (79) | 0.818 |
| HAM-A | 3.0 (2.5-3.5) | 2.9 (2.3-3.5) | 3.1 (2.4-3.9) | 0.969 |
| 5-HT1A Variant*1 | 0.522 | |||
| C/C | 22.7 (39) | 25.6 (22) | 19.8 (17) | |
| C/G | 49.4 (85) | 45.4 (39) | 53.5 (46) | |
| G/G | 27.9 (48) | 29.1 (25) | 26.7 (23) | |
| 5-HT1A Allele Frequency* | 0.746 | |||
| C Allele | 0.47 (163) | 0.48 (83) | 0.47 (80) | |
| G Allele | 0.53 (181) | 0.52 (89) | 0.53 (92) | |
| Cannabis Use | ||||
| Characteristics | ||||
| Age of Dependence Onset | 19.8 (19.1-20.5) | 19.6 (18.8-20.5) | 20.0 (18.9-21.2) | 0.857 |
| Percent of days Using | 85.2 (82.5-87.8) | 85.0 (81.3-88.8) | 85.3 (81.6-89.1) | 0.964 |
| Sessions Per Day | 3.2 (2.8-3.5) | 2.9 (2.6-3.3) | 3.4 (2.8-3.9) | 0.477 |
| Joints/bowls Per Day | 3.8 (3.5-4.2) | 3.8 (3.3-4.3) | 3.9 (3.3-4.5) | 0.726 |
| MCQ Total Score | 46.1 (43.9-48.3) | 46.4 (43.0-49.9) | 45.8 (42.8-48.7) | 0.777 |
| MCQ Compulsivity Score | 7.9 (7.3-8.6) | 7.8 (7.0-8.7) | 8.1 (7.1-9.0) | 0.817 |
| MCQ Emotionality Score | 10.8 (10.1-11.5) | 11.0 (9.9-12.1) | 10.6 (9.6-11.5) | 0.741 |
| MCQ Expectancy Score | 13.2 (12.5-13.9) | 13.6 (12.6-14.7) | 12.7 (11.8-13.6) | 0.102 |
| MCQ Purposefulness Score | 14.1 (13.3-14.8) | 14.0 (12.9-15.1) | 14.1 (13.1-15.2) | 0.874 |
Continuous characteristics are noted as Mean and associated 95% confidence interval and categorical Characteristics are noted as % (n).
*
Data available on 172 participants (86 Buspirone and 86 Placebo).
1
χ21=0.013; p=0.91 for study population consistent with Hardy-Weinberg equilibrium.