Plasma from patients obtained on Day 0 and Day 56 were analyzed via bioplex analysis for the expression of 54 soluble cytokine and chemokine mediators. (A) Data are presented as the mean fold change in expression for each factor across the 23 patients who were evaluable on study with adequate samples for analysis. Significantly reduced levels of both canonical pro-inflammatory cytokines (IL-1β, TGF-β, TNF-α, IFN-γ; shown in blue) and MDSC-associated cytokines (G-CSF, IL-6, GM-CSF, M-CSF, IL-10, IL-13, VEGF); shown in red) were observed following dietary soy intervention. (B) Representative raw data for plasma IL-6 (in pg/mL) from patients prior to (Day 0) and following soy intervention (Day 56).