Table 1.
Dysregulated microRNAs (miRNAs) in lungs of patients with idiopathic pulmonary fibrosis (IPF).
| S. NO | Upregulated miRNA | Downregulated miRNA | Validation method | Tissue/cell type | Reference |
|---|---|---|---|---|---|
| 1 | miR-409-3p, miR-92b, miR-376a, miR-205, miR-31, miR-765, miR-199b, miR-198, miR-622, miR-330, miR-379, miR-659, miR-182, miR-487b, miR-299-5p, miR-127, miR-296, miR-509, miR-557, miR-134, miR-491, miR-132, miR-155, miR-99a, miR-324-3p, miR-214, miR-199a, miR-320 | let-7d, miR-125a, miR-126, miR-138, miR-17-3p, miR-184, miR-197, miR-203, miR-224, miR-26a, miR-30a-3p, miR-30a-5p, miR-30b, miR-30c, miR-30d, miR-338, miR-362 and miR-92 | microRNA micro arrays | Lungs | Pandit et al., 2010 |
| 2 | miR-21 | In situ hybridization | Lungs | Liu et al., 2010b | |
| 3 | miR-21 | miR-200c | In situ hybridization and qRT-PCR | Alveolar type II cells of lungs | Yamada et al., 2013 |
| 4 | miR-200a and c | qRT-PCR | Lungs | Yang et al., 2012 | |
| 5 | miR-31, miR-31∗, miR-493∗, miR-76a, miR-382, miR-127-3p, miR-410, miR-376c, miR-432, miR-377, miR-654-3p, miR-409-3p, miR-381, miR-299-5p, miR-1, miR-487b, miR-133b, miR-370, miR-513c, miR-299-3p, miR-543, miR-369-5p, miR-154, miR-1225-5p, miR-409-5p, miR-379, miR-650, miR-143∗, miR-495, miR-513a-5p, miR-143, miR-214∗, miR-411, miR-199b-5p, miR-199a-5p, miR-199b-3p, miR-376a∗, miR-27b, miR-539, miR-585, miR-509-5p, miR-10a∗ and miR-509-3-5p | miR-33a∗, miR-151-3p, miR-361-3p, miR-181a, miR-374b, miR-425, miR-222, miR-532-3p, miR-17, let-7d, miR-668, miR-30c-1∗, miR-548c-3p, miR-532-5p, miR-362-5p, miR-342-5p, miR-181b, miR-885-5p, miR-181a∗, miR-517b, miR-520g, miR-628-3p, miR-340∗, miR-744∗, miR-652, miR-502-3p, miR-29b-1∗, miR-30a∗, miR-30a, miR-30d, miR-7-1∗, miR-500∗, miR-181d, miR-210, miR-30c-2∗, miR-224, miR-30b∗, miR-223, miR-221∗, miR-126, miR-502-5p, miR-375, miR-522, miR-598, miR-326, miR-489, miR-223∗, miR-30b, miR-203, miR-338-3p and miR-184 | microRNA micro arrays | Lungs | Milosevic et al., 2012 |
| 6 | miR-29 | qRT-PCR | Lungs | Montgomery et al., 2014 | |
| 7 | miR-375 | qRT-PCR | Lungs | Wang et al., 2013 | |
| 8 | miR-199a-5p | qRT-PCR and In situ hybridization | Selectively increased in fibrotic foci of lungs | Lino Cardenas et al., 2013 | |
| 9 | miR-17 ∼ 92 cluster | qRT-PCR and In situ hybridization | Lungs and fibroblasts | Dakhlallah et al., 2013 | |
| 10 | miR-326 | qRT-PCR | Lungs | Das et al., 2014 | |
| 11 | miR-96 | qRT-PCR and In situ hybridization | Lungs and fibroblasts | Nho et al., 2014 | |
| 12 | miR-338-3p, miR-126-3p, miR-30d-5p, miR-203a, miR-30b-5p, miR-30a-5p, miR-101-3p, miR-126-5p, miR-375, miR-218-5p, miR-92a-3p, miR-222-3p, miR-26b-5p, miR-125a-5p, miR-138-5p, miR-184, miR-26a-5p, miR-326, miR-211-5p, miR-598-3p, miR-452-3p, miR-643, miR-621, miR-512-5p, miR-569, miR-33a-3p, miR-581, miR-517b-3p, let-7d-5p and let-7g-5p | MicroRNA micro arrays | Lungs | Berschneider et al., 2014 | |
| 13 | miR-26a | qRT-PCR | Lungs | Liang et al., 2014b | |
| 14 | miR-382, miR-449a, miR-642, miR-205, miR-31, miR-34b, miR-376b and miR-376c | miR-378, miR-422a, miR-425, miR-497, miR-500, miR-660, miR-663, miR-744, miR-92a, miR-93, miR-101, miR-103, miR-106a, miR-106b, miR-1271, miR-130a, miR-130b, miR-138, miR-141, miR-150, miR-15a, miR-15b, miR-17, miR-181b, miR-181c, miR-181d, miR-184, miR-185, miR-18a, miR-191, miR-193b, miR-194, miR-197, miR-19a, miR-19b, miR-203, miR-20a, miR-20b, miR-22, miR-221, miR-222, miR-223, miR-23a, miR-24, miR-25, miR-26a, miR-27a, miR-29a, miR-29b, miR-29c, miR-30a, miR-30b, miR-30c, miR-30d, miR-30e, miR-320a, miR-320b, miR-320c, miR-320d, miR-335, miR-345 and miR-375 | microRNA micro arrays | Lungs | Liang et al., 2014a |
| 15 | miR-210 | In situ hybridization | Lungs | Bodempudi et al., 2014 | |
∗indicates passenger strand.