CALCITONIN RECEPTOR FAMILY |
Calcitonin receptor (CTR) |
Calcitonin |
Ca2+ homeostasis |
Osteoporosis |
Miacalcin, Fortical |
Amylin receptors (AMY1, AMY2, AMY3) |
Amylin |
Energy homeostasis and body fluid balance |
Diabetes/obesity |
Pramlintide |
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Amyloid-beta (Aβ) protein |
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Calcitonin gene-related peptide receptor (CGRP receptor) |
α-calcitonin gene-related peptide (α-CGRP) |
Vasodilation and nociception |
Migraine |
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ß-CGRP |
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Adrenomedullin receptors (AM1, AM2) |
adrenomedullin 1 |
Vasodilation |
Cardiovascular disease, cancer |
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adrenomedullin 2 |
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GLUCAGON RECEPTOR FAMILY |
Glucagon receptor (GCGR) |
Glucagon |
Regulation of blood glucose |
Diabetes |
Glucagon |
Glucagon-like peptide 1 receptor (GLP-1R) |
Glucagon-like peptide 1 (GLP-1) |
Insulin and glucagon secretion |
Diabetes |
Exenatide, Lixisenatide, Liraglutide, Albiglutide, Dulaglutide |
Glucagon-like peptide 2 receptor (GLP-2R) |
Glucagon-like peptide 2 (GLP-2) |
Gut mucosal growth |
Short bowel syndrome, Crohn's disease, osteoporosis |
Teduglutide |
Gastric inhibitory polypeptide receptor (GIPR) |
Gastric inhibitory polypeptide (GIP) |
Insulin secretion, fatty acid metabolism |
Diabetes/obesity |
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CORTICOTROPIN-RELEASING HORMONE RECEPTORS |
Corticotropin-releasing factor receptor 1 (CRF1R) |
Corticotropin-releasing factor (CRF) |
Release of ACTH and central stress responses |
Stress, inflammatory bowel syndrome |
Corticorelin |
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Urocortin I (Ucn1) |
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Corticotropin-releasing factor receptor 2 (CRF2R) |
CRF |
Central stress responses, cardiac contractility, hearing |
Cancer, heart failure, hypertension |
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Urocortin II (Ucn2) |
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Urocortin III (Ucn3) |
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PARATHYROID HORMONE RECEPTORS |
Parathyroid hormone 1 receptor (PTH1R) |
Parathyroid hormone (PTH) |
Ca2+ homeostasis |
Osteoporosis, hypoparathyroidism |
Teriparatide, Preotact |
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Parathyroid hormone-related protein (PTHrP) |
Developmental regulator |
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Parathyroid hormone 2 receptor (PTH2R) |
PTH |
Hypothalamic secretion, nociception |
Nociception |
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Tuberoinfundibular peptide of 39 residues (TIP39) |
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VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTORS |
Vasoactive intestinal polypeptide receptor 1 (VPAC1R) |
Vasoactive intestinal polypeptide (VIP) |
Vasodilation, neurotransmission, neuroendocrine functions |
Inflammation, neurodegeneration |
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PACAP |
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Vasoactive intestinal polypeptide receptor 2 (VPAC2R) |
VIP |
Vasodilation, neurotransmission neuroendocrine functions |
Inflammation, neurodegeneration |
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PACAP |
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OTHERS |
Pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1R) |
Pituitary adenylate cyclase-activating polypeptide (PACAP) |
Neurotransmission neuroendocrine functions |
Neurodegeneration nociception, glucose homeostasis |
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Growth-hormone-releasing hormone receptor (GHRHR) |
Growth hormone-releasing hormone (GRHR) |
Release of growth hormone |
Dwarfism, HIV-related lipodystrophy |
Tesamorelin, Sermorelin, CJC-1295 |
Secretin receptor (SCTR) |
Secretin |
Pancreatic secretion |
Autism, schizophrenia, duodenal ulcers, gastrinoma |
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