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. 2015 Nov 5;5:15942. doi: 10.1038/srep15942

Figure 3. Blood glucose, glucose intolerance and serum insulin test of Leptin receptor knockout rat.

Figure 3

(A–D) Fasting and random blood glucose were measured over 8 month for male WT littermate (n = 19), male Lepr−/− rat (n = 12), female WT littermate (n = 13) and female Lepr−/− rat (n = 15). (E,F) 2, 4 and 8months of age WT littermate and Lepr−/− rat (n = 8 for each group) in both genders were administrated with D-glucose, and serum glucose levels were determined at 0, 30, 60, 90 and 120 min after administration. (G,H) Serum insulin levels of WT littermate and Lepr−/− rat (n = 4 for each group) in both genders were measured in glucose tolerance tests meanwhile. *P < 0.05, **P < 0.01, ***P < 0.001 versus WT littermates in Figure 3A-3D; # refers to differences between WT-2M and Lepr−/−-2M; & refers to differences between WT-4M and Lepr−/−-4M and * refers to differences between WT-8M and Lepr−/−-8M in Fig. 3E–H; #, & and *P < 0.05, ##, && and **P < 0.01, ###, &&& and ***P < 0.001.