Table 1. Fasting serum biochemistry at 2, 4 and 8 months of age.
| Group | 2M |
4M |
8M |
|||
|---|---|---|---|---|---|---|
| WT | Lepr−/− | WT | Lepr−/− | WT | Lepr−/− | |
| Number | 11 | 6 | 8 | 9 | 7 | 7 |
| CHO (mM) | 1.56 ± 0.73 | 2.46 ± 0.56 * | 1.69 ± 0.76 | 5.89 ± 1.04 *** | 1.94 ± 0.76 | 8.15 ± 2.70 *** |
| TG (mM) | 0.81 ± 0.39 | 2.84 ± 0.90 *** | 1.16 ± 0.55 | 5.00 ± 2.08 *** | 1.20 ± 0.78 | 6.26 ± 3.08 ** |
| HDL (mM) | 1.11 ± 0.55 | 1.78 ± 0.63 * | 0.91 ± 0.49 | 3.73 ± 0.95 *** | 1.44 ± 0.63 | 5.89 ± 2.28 *** |
| LDL (mM) | 0.21 ± 0.10 | 0.32 ± 0.22 | 0.23 ± 0.12 | 0.29 ± 0.07 | 0.21 ± 0.05 | 0.76 ± 0.27 *** |
CHO, total cholesterol; TG, triglycerides; HDL, high density lipoprotein; LDL, low density lipoprotein.
*P < 0.05, **P < 0.01, *** P < 0.001 versus WT littermate.