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. 2015 Oct 7;6:8385. doi: 10.1038/ncomms9385

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(a) Schematic of peptide bond formation to give oligomers from amino acid monomers. (b) Process flow scheme for the APS system: amino acid starting material is added and dehydrated for a given time (t), then rehydrated/dehydrated for a given number of cycles (n), after which the product outputs are removed for analysis. Single amino acid monomers (A, B and so on) may be added or, alternatively, defined amino acid 2-3-mer fragments (A_n and B_n) can be used as starting materials. Reaction outcome is controlled by selection of input variables and process variables, and the overall reaction time is simply the time per cycle × the number of cycles.