Table 3. pAID joint heritabilities or genetic correlation (rG) reaching nominal significance.
| pAID pair | rG (auto) | s.e. | Pval | rG (exMHC) | s.e. | P_nominal | P_adj |
|---|---|---|---|---|---|---|---|
| CVID-JIA | 0.343 | 0.127 | 1.22E–03 | 0.354 | 0.142 | 2.47E–03 | 2.23E–02 |
| EPI-JIA | −0.150 | 0.079 | 2.95E–02 | −0.142 | 0.085 | 4.87E–02 | 0.44 |
| EPI-UC | 0.197 | 0.103 | 2.77E–02 | 0.248 | 0.108 | 1.06E–02 | 0.10 |
| PS-T1D | −0.241 | 0.139 | 3.29E–02 | −0.282 | 0.167 | 3.74E–02 | 0.34 |
| PS-UC | −0.316 | 0.169 | 2.31E–02 | −0.289 | 0.171 | 3.76E–02 | 0.34 |
| SLE-CD | −0.266 | 0.120 | 8.25E–03 | −0.255 | 0.121 | 1.15E–02 | 0.10 |
| SPA-CD | −0.215 | 0.138 | 4.64E–02 | −0.235 | 0.156 | 4.67E–02 | 0.42 |
| T1D-CD | 0.096 | 0.053 | 3.45E–02 | 0.142 | 0.064 | 1.33E–02 | 0.12 |
| UC-CD | 0.659 | 0.069 | <1.00E–04 | 0.674 | 0.072 | <1.00E–04 | 9.00E–04 |
Auto, autosomal; CD, crohn's disease; CEL, celiac disease; CVID, common variable immunodeficiency disorder; EPI, epilepsy; JIA, juvenile idiopathic arthritis; NA, not applicable; pAID, paediatric autoimmune disease; PS, psoriasis; exMHC, MHC excluded; SLE, systemic lupus erythematosus; SPA, spondyloarthropathy; T1D, type 1 diabetes; UC, ulcerative colitis.
P-values (P) are based on results from the restricted maximum likelihood estimate (likelihood ratio test). P_adj is made using a Bonferonni-adjustment for nine pairwise tests for each disease.