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. 2015 Oct 22;2015:560347. doi: 10.1155/2015/560347

Table 2.

Broadly neutralizing antibodies, target sites, and breadth of neutralization.

Broadly neutralizing antibodies Target site Breadth of neutralization
(IC50 < 50 μg/mL)		 Study
VRC01 CD4 binding site 89% of 180 isolates Huang et al. (2012) [32]
VRC02 CD4 binding site 91% of 190 isolates Wu et al. (2010) [33]
VRC03 CD4 binding site 57% of 190 isolates Wu et al. (2010) [33]
VRC-PGV04 CD4 binding site 88% of 162 isolates Walker et al. (2011) [34]
VRC-PGV04b CD4 binding site 71% of 178 isolates Wu et al. (2011) [35]
CH103 CD4 binding site 55% of 196 isolates Liao et al. (2013) [22]
2F5 gp41 39% of 92 isolates Corti et al. (2010) [36]
2G12 gp120 41% of 90 isolates Binley et al. (2004) [37]
4E10 gp41 98% of 162 isolates Walker et al. (2009) [38]
PG9 V1-V2 loops 78% of 180 isolates Huang et al. (2012) [32]
PGT130 V3 loop 52% of 162 isolates Walker et al. (2011) [34]
PGT151 gp120-gp41 66% of 117 cross-clade isolates Bonsignori et al. (2014) [39]
PGT152 gp120-gp41 64% of 117 cross-clade isolates Blattner et al. (2014) [40]