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. 2015 Nov 5;5:16271. doi: 10.1038/srep16271

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Copyright © 2015, Macmillan Publishers Limited

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BTB integrity assay was performed to assess the ability of an intact BTB to block the movement of FITC-inulin across the BTB from the basal compartment near the basement membrane (annotated by “white” dotted line) to the adluminal compartment. Results of the BTB integrity assay were shown in normal testis (Ctrl, A), testis treated with F5-peptide at 320 μg/testis (F5, B), or testis pre-transfected with non-targeting control siRNA (Ctrl RNAi+F5, C) or Slc15a1 siRNA (Slc15a1 RNAi+F5, D). Scale bar = 150 μm. (E) Histogram summarizing data based on findings shown in (A–D) by comparing the distance of FITC-inulin diffused into the epithelium (D_FITC) (annotated by the “white bracket”) vs. the radius of a seminiferous tubule (D_STr) (the average of the longest and shortest semi-axes for sections of oval-shaped tubules) (n = 200 tubules from testes of 3 rats in each group). ^**P < 0.01.