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. 2015 Nov 5;5:16273. doi: 10.1038/srep16273

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(A) Self-cleavage mechanism of 2A self-cleaving peptide. The cleavage site locates between glycine (G) and praline (P) at its C-terminus. After self-cleavage, amino acids residues at the N-terminus of 2A linked to upstream protein and its last praline residue remained to the downstream protein, but the residues of 2A could be removed through furin and signal peptide⁹. (B) Sequence analysis of six 2As which was respectively from porcine teschovirus-1 2A (P2A), thoseaasigna virus 2A (T2A), equine rhinitis a virus 2A (E2A), foot and mouth disease virus 2A (F2A), cytoplasmic polyhedrosis virus 2A (BmCPV2A) and flacherie Virus 2A (BmIFV2A).