Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Feb 9;34(42):5395–5405. doi: 10.1038/onc.2014.468

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Schematic overview of HACE1 loss in breast cancer. The overexpression of HER2 results in Rac1 activation by homo- or hetero-dimerization of HER family members. Ubiquitylation of Rac1 occurs upon activation when HACE1 is present and Rac1 is degraded via the 26 S proteasome. When HACE1 is lost, activated Rac1 accumulated in the cell driving proliferation, cell survival, migration and invasion.