Table 3.
Incidence rates and adjusted hazard ratios of incident CKD in relation to stone former history (yes or no) and uric acid level (high or low) in 10,608 Atherosclerosis Risk in Communities study participants
| Stone Former | Plasma Uric Acid Level | Number of Participants | Number of CKD Events | CKD Events per 1,000 Person-Years (95% CI) | Model 1, Hazard Ratio (95% CI) | Model 2, Hazard Ratio (95% CI) |
|---|---|---|---|---|---|---|
| Time-varying analyses | ||||||
| Yes | >6 | 452 | 53 | 11.2 (8.6 to 14.7) | 1.48 (1.11 to 1.98)a | 0.94 (0.70 to 1.28) |
| ≤6 | 717 | 85 | 11.5 (9.3 to 14.2) | 1.65 (1.31 to 2.08)a | 1.34 (1.05 to 1.72)a | |
| No | >6 | 3109 | 409 | 11.0 (10.0 to 12.1) | 1.54 (1.34 to 1.76)a | 1.11 (0.96 to 1.28) |
| ≤6 | 6330 | 479 | 6.1 (5.6 to 6.7) | 1 (reference) | 1 (reference) | |
| Baseline analyses | ||||||
| Yes | >6 | 321 | 37 | 9.8 (7.1 to 13.6) | 1.35 (0.96 to 1.89) | 0.83 (0.58 to 1.19) |
| ≤6 | 528 | 67 | 10.9 (8.5 to 13.8) | 1.58 (1.22 to 2.04)a | 1.22 (0.93 to 1.61) | |
| No | >6 | 3240 | 432 | 11.4 (10.4 to 12.5) | 1.54 (1.34 to 1.76)a | 1.10 (0.95 to 1.27) |
| ≤6 | 6519 | 502 | 6.3 (5.8 to 6.9) | 1 (reference) | 1 (reference) |
Uric acid levels were missing in 70 participants at visit 4. Model 1 was adjusted for age, sex, race, and study center. Model 2 was adjusted for the demographic factors in model 1 as well as HDL, hypertension, urine albumin-to-creatinine ratio, eGFR, plasma uric acid (linear spline with knot at 6 mg/dl), diuretic use, smoking status, body mass index, diabetes, history of coronary heart disease, and high-sensitivity C-reactive protein. 95% CI, 95% confidence interval.
a
P<0.05.