Table 1.
Characteristic of patients in the study (N=57)
| Characteristic | Recovery Group (n=29) | Nonrecovery Group (n=28) | P Value |
|---|---|---|---|
| Patient characteristics at inclusion | |||
| Age (yr) | 66 (60–74) | 70 (61–79) | 0.22 |
| Men | 15 (52) | 21 (75) | 0.10 |
| Weight (kg) | 72 (62–83) | 75 (66–95) | 0.42 |
| Body mass index (kg/m2) | 26 (23–30) | 26 (23–32) | 0.74 |
| SOFA score | 5 (3–6) | 8 (4–12) | 0.01 |
| SOFA without renal component | 4 (3–6) | 7 (2–11) | 0.08 |
| SAPS-II score | 40 (26–47) | 59 (35–72) | 0.003 |
| Mechanical ventilation | 7 (24) | 12 (43) | 0.17 |
| Mean arterial pressure (mmHg) | 76 (68–90) | 75 (67–85) | 0.68 |
| NE infusion | 6 (21) | 12 (43) | 0.09 |
| Dose of NE (μg/kg per minute) | 0.43 (0.13–0.67) | 0.37 (0.16–0.79) | >0.99 |
| Lactate (mg/dl) | 13.5 (9–16.2) | 18 (13.5–31.5) | 0.02 |
| PaO2/FiO2 ratio | 247 (205–303) | 239 (145–319) | 0.61 |
| Reasons for ICU admission | 0.29 | ||
| Severe sepsis/septic shock | 5 (17)/6(21) | 2 (7)/10 (36) | |
| Major surgery | 11 (38) | 8 (29) | |
| Acute respiratory failure | 5 (17) | 3 (11) | |
| Acute hemorrhage | 1 (3) | 2 (7) | |
| Acute pancreatitis | 1 (3) | 1 (4) | |
| Acute liver failure | 0 (0) | 2 (7) | |
| Infection source | 0.81 | ||
| Intra-abdominal | 6 (46) | 7 (64) | |
| Pulmonary | 3 (23) | 2 (18) | |
| Mediastinal | 2 (15) | 1 (9) | |
| Biliary | 2 (15) | 1 (9) | |
| Prior kidney function | |||
| Baseline creatinine (mg/dl) | 0.8 (0.6–0.9) | 0.9 (0.7–1.1) | 0.02 |
| eGFR (ml/min per 1.73 m2)a | 95 (79–99) | 78 (59–98) | 0.05 |
| Renal function at inclusion | |||
| Diuresis (ml/h) | 0.46 (0.33–0.61) | 0.24 (0.12–0.37) | <0.001 |
| Serum urea (mg/dl) | 24.6 (15.7–31.9) | 32.2 (28.3–52.9) | 0.004 |
| Serum creatinine (mg/dl) | 1.2 (0.7–1.5) | 1.9 (1.3–2.9) | <0.001 |
| KDIGO stage at inclusion | <0.001 | ||
| 1 | 7 (24) | 1 (4) | |
| 2 | 20 (69) | 10 (36) | |
| 3 | 2 (7) | 17 (61) | |
| Fluid balance (ml)b | 1910 (1300–2700) | 2670 (1860–3270) | 0.04 |
| Evolution | |||
| Maximum KDIGO stage reached | <0.001 | ||
| 1 | 6 (21) | 1 (4) | |
| 2 | 21 (72) | 5 (18) | |
| 3 | 2 (7) | 22 (79) | |
| RRT | 0 (0) | 9 (32) | <0.001 |
| ICU, length of stay (d) | 6 (4–8) | 8 (6–20) | 0.01 |
| Hospital, length of stay (d) | 15 (13–25) | 27 (13–52) | 0.17 |
| ICU mortality | 2 (7) | 6 (21) | 0.14 |
| Hospital mortality | 2 (7) | 12 (43) | 0.004 |
| Major adverse kidney eventsc | 2 (7) | 14 (50) | <0.001 |
Data are expressed as medians (interquartile ranges) or n (%). SOFA, Sequential Organ Failure Assessment; SAPS, Simplified Acute Physiology Score; ICU, intensive care unit; KDIGO, Kidney Disease Improving Global Outcomes.
a
Calculated using the Chronic Kidney Disease Epidemiology Collaboration formula.
b
Calculated the day of admission.
c
Major adverse kidney events at hospital discharge truncated at 30 days.