Skip to main content
. 2015 Oct 12;6:8521. doi: 10.1038/ncomms9521

Figure 3. Variability of theta amplitude mediates speed variability.

Figure 3

(a) Distribution of theta oscillation epochs according to variability of theta cycles amplitude (spontaneous theta, black, n=384 recording epochs, N=8 mice; optogenetic stimulation, blue, n=818 recording epochs, N=8 mice). (b,c) Both in control and during optogenetic theta entrainment, theta amplitude variability predicted changes of speed variability (b, polynomial fit, R2=0.89, spontaneous theta; R2=0.90, optogenetic stimulation) and of running speed (c, R2=0.96, spontaneous theta; R2=0.92, optogenetic stimulation). (d) Changes of theta amplitude correlated with changes of firing probability in CA1 pyramidal cells during spontaneous and optogenetically entrained theta (25 and 12 single units, respectively; polynomial fit, R2=0.90, spontaneous theta; R2=0.88, optogenetic stimulation). Data are presented as mean±s.e.m.