Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
MiR-148a promotes starvation-induced autophagic activity in HSCs, at least in part, through suppressing the Hedgehog signaling pathway. Starvation stimulates the upregulation of miR-148a expression, miR-148a can directly interact with the 3’-UTRs of the Gas1 mRNA and followed by inhibit Hedgehog pathway activity, resulting in increased autophagosome accumulation. MiR-148a inhibits proliferation and promotes apoptosis by inducing autophagy in HSCs.
