Figure 5.

The proposed dysregulation mechanisms around ESRRG. A. ESRRG-centered subnetworks out of the three GRNs corresponding to normal, adenoma and carcinoma. ESRRG is a target, and the other nodes are its regulators. Nodes in solid-line ovals represent DRL related targets; nodes in dotted-line ovals are unrelated to DRLs. Links in red, green and grey represent positive, negative and absent regulation relationships calculated with dataset GES24375; Links in bold are DRL related. Numbers on the links indicate the regulation efficacies. B. The proposed mechanisms by which ESRRG induces gastric carcinoma. Links in red, green and grey still represent positive, negative and absent regulation relationships at normal (Nm), adenoma (Ad) and carcinoma (Ca) stage calculated with dataset GES24375. The darker the color, the larger the absolute regulation efficacy. Links in black are gene-gene interconnections obtained from literatures. The color of gene symbol, red or green, represents up- or down-expression in stage transition according to dataset GES24375 and TCGA data. Boxes indicate biological processes, with red color referring to activation and green color referring to inhibition.