Table 2.

Topological comparison of adjacent stage-specific GRNs

Stages	Out-Deg	In-Deg	Bet	CC	Cls
Normal_GRN*	39.9	1.68	0.83	0.036	3.70E-06
Normal vs. Adenoma (p-value)	0.638	0.0167	0.72	2.87E-08	< 2.2e-16
Adenoma_GRN*	53.3	1.53	0.78	0.163	1.70E-06
Adenoma vs. Carcinoma (p-value)	0.24	0.24	0.38	0.033	< 2.2e-16
Cancer_GRN*	37.09	1.42	0.709	0.1428	3.04E-06

^*Means the mean value of a topological measure of a GRN.

Topological difference significance (p-value) was calculated by Wilcoxon rank-sum test.