Table 4.
Enrichment analysis of cancer genes and drug targets in common and differential targets
| Comparison | Groups | No. of targets | No. of Control Genes | No. of cancer genes (p-value) | No. of drug targets (p-value) |
|---|---|---|---|---|---|
| Normal vs. Adenoma | Common | 132 | 12526 (12658-132) | 4 (0.785) | 26 (0.027) |
| Differential | 770 | 11888 (12658-770) | 33 (0.012) | 134 (0.0003) | |
| Adenoma vs. Carcinoma | Common | 145 | 12513 (12658-145) | 6 (0.297) | 25 (0.137) |
| Differential | 781 | 11877 (12658-781) | 32 (0.023) | 148 (1.67e-6) |
The significance (p-value) of the enrichment of cancer genes or drug targets in a targets group was calculated by Fisher’s Exact Test. The 12658 genes assayed by Affymetrix Microarray GPL10982 were taken as the respondents population. The calculation of the p values of every “common” or “differential” groups were displayed in Table S1.