Figure 1.

Expression of miR-449a was negatively correlated with metastasis of lung cancer. A. MicroRNA chips show the significant downregulation of miR-449a in L9981 cells which have strong metastatic ability. B. Detection of miR-449a expression in lung cancer cells with different metastasis ability using real-time PCR. C. Metastatic lymph node tissues showed lower expression of miR-449a compared with cancer tissues in 30 cases of matched clinical specimens. Statistical significance is indicated as: P<0.001, Student’s t test.