Table 1.
Frequency of EGFR mutations in patients with NSCLC of ADC histology by country
| Country | No. studies | EGFR mutation frequency | ||
|---|---|---|---|---|
|
| ||||
| No. patients with an EGFR mutation/total no. patients | Overall EGFR mutation frequency (%) | EGFR mutation frequency range (%) | ||
| Asia-Pacific | ||||
| Overall | 87 | 5958/12819 | 47 | 20-76 |
| China | 18 [27,34-50] | 1403/2949 | 48 | 27-66 |
| Hong Kong | 3 [27,51,52] | 312/585 | 53 | 47-58 |
| Japan | 33 [53-84] | 2069/4619 | 45 | 21-68 |
| Malaysia | 2 [85,86] | 272/599 | 45 | 39-47 |
| Philippines | 1 [27] | 34/65 | 52 | N/A |
| Republic of Korea | 17 [87-103] | 1248/2884 | 43 | 20-56 |
| Singapore | 2 [104,105] | 57/142 | 40 | 39-43 |
| Taiwan | 9 [27,75,106-112] | 423/739 | 57 | 36-76 |
| Thailand | 1 [27] | 63/117 | 54 | N/A |
| Vietnam | 1 [27] | 77/120 | 64 | N/A |
| Europe | ||||
| Overall | 39 | 1527/10464 | 15 | 6-41 |
| Austria | 1 [113] | 7/96 | 7 | N/A |
| Czech Republic | 1 [114] | 21/101 | 21 | N/A |
| Finland | 1 [115] | 58/398 | 10 | N/A |
| France | 2 [116,117] | 193/1289 | 15 | 15-17 |
| Germany | 7 [118-124] | 175/1573 | 11 | 6-41 |
| Greece | 2 [125,126] | 30/137 | 22 | 20-22 |
| Italy | 9 [127-135] | 306/2223 | 14 | 10-33 |
| Lithuania | 1 [136] | 8/65 | 12 | N/A |
| The Netherlands | 2 [13,137] | 162/1110 | 15 | 11-20 |
| Norway | 1 [138] | 16/141 | 11 | N/A |
| Poland | 3 [139-141] | 88/678 | 13 | 11-14 |
| Portugal | 1 [142] | 29/216 | 13 | N/A |
| Russia | 2 [143,144] | 53/240 | 22 | 20-31 |
| Slovakia | 1 [145] | 56/285 | 20 | N/A |
| Spain | 1 [146] | 283/1634 | 17 | N/A |
| Sweden | 1 [147] | 16/148 | 11 | N/A |
| Turkey | 2 [148,149] | 15/41 | 37 | 22-41 |
| UK | 1 [150] | 11/89 | 12 | N/A |
| North America | ||||
| Overall | 19 | 1638/7396 | 22 | 3-42 |
| Canada | 2 [151,152] | 84/612 | 14 | 14 |
| USA | 16 [7,75,153-165] | 1531/6663 | 23 | 3-42 |
| USA (African Americans) | 1 [166] | 23/121 | 19 | N/A |
| Indian subcontinent | ||||
| Overall | 5 | 278/1090 | 26 | 22-27 |
| Bangladesh | 1 [167] | 14/61 | 23 | N/A |
| India | 3 [27,168,169] | 261/1018 | 26 | 22-26 |
| Pakistan | 1 [170] | 3/11 | 27 | N/A |
| South America | ||||
| Overall | 5 | 250/686 | 36 | 9-67 |
| Argentina | 1 [30] | 47/244 | 19 | N/A |
| Brazil | 3 [171-173] | 67/239 | 28 | 9-34 |
| Peru | 1 [30] | 136/203 | 67 | N/A |
| Oceania | ||||
| Overall | 4 | 69/570 | 12 | 7-36 |
| Australia | 4 [75,174-176] | 69/570 | 12 | 7-36 |
| Africa | ||||
| Overall | 1 | 29/137 | 21 | N/A |
| Morocco | 1 [177] | 29/137 | 21 | N/A |
ADC adenocarcinoma, EGFR epidermal growth factor receptor, N/A not available, NSCLC non-small-cell lung cancer.