Table 2.

Frequency of EGFR mutations in patients with NSCLC of ADC histology by gender and country

Country	No. studies	EGFR mutation frequency
		Males			Females
		No. patients with an EGFR mutation/total no. patients	Overall EGFR mutation frequency (%)	EGFR mutation frequency range (%)	No. patients with an EGFR mutation/total no. patients	Overall EGFR mutation frequency (%)	EGFR mutation frequency range (%)
Asia-Pacific
Overall	20	473/1250	37	20-80	763/1263	60	0-83
China	4 [36,40,46,49]	41/86	48	25-80	43/62	69	29-83
Hong Kong	1 [51]	28/84	33	N/A	87/131	66	N/A
Japan	10 [60,61,65,68,69,74,76,77,80,82]	345/893	39	34-67	534/866	62	0-76
Republic of Korea	4 [87,89,94,95]	41/152	27	20-36	75/162	46	38-80
Taiwan	1 [111]	18/35	51	N/A	24/42	57	N/A
Europe
Overall	9	88/1035	9	4-18	133/616	22	3-35
Austria	1 [113]	3/58	5	N/A	4/38	11	N/A
Germany	2 [118,120]	15/211	7	4-12	27/163	17	14-23
Greece	1 [125]	3/17	18	N/A	1/3	33	N/A
Italy	3 [127,133,135]	26/323	8	6-13	49/215	23	13-35
Poland	1 [140]	25/310	8	N/A	30/121	25	N/A
Russia	1 [143]	16/116	14	N/A	22/76	29	N/A
North America
Overall	2	175/923	19	8-20	459/1656	28	21-28
USA	2 [7,157]	175/923	19	8-20	459/1656	28	21-28
Indian subcontinent
Overall	3	160/689	23	23-26	99/318	31	14-33
Bangladesh	1 [167]	12/47	26	N/A	2/14	14	N/A
India	2 [168,169]	148/642	23	23	97/304	32	32-33
Africa
Overall	1	7/91	8	N/A	22/46	48	N/A
Morocco	1 [177]	7/91	8	N/A	22/46	48	N/A

ADC adenocarcinoma, EGFR epidermal growth factor receptor, N/A not available, NSCLC non-small-cell lung cancer.