Table 3.
Summary of 5-FU pharmacokinetics for 400, 500, and 650 mg/m2
| 5-FU Dosage, mg/m2, median (range) |
|||
|---|---|---|---|
| 400 | 500 | 650 | |
| N | 17 | 42 | 13 |
| Cmax, µM | 532 (324–940) | 825 (108–2076) | 711 (260–1734) |
| Tmax, min | 6 (5–7) | 6 (4–10) | 6 (5–14) |
| t1/2, min | 6.9 (5.6–7.8) | 9.9 (4.7–19.8) | 11.2 (7.7–20.7) |
| AUC0–∞, µM × h | 115 (88.9–179) | 205 (58.6–468) | 190 (157–468) |
| CL, L/h/m2 | 26.8 (17.2–34.6) | 18.8 (8.2–65.6) | 26.2 (10.7–31.9) |
Abbreviations: N, number of pharmacokinetic studies per dose group; Cmax, observed maximum plasma concentration; Tmax, time to maximum concentration; t1/2, terminal α half-life; AUC0–∞, area under the plasma concentration–time curve from time zero to infinity; CL, clearance.