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. 2015 Oct 19;6:8324. doi: 10.1038/ncomms9324

Figure 3. Enhancers primed in HSCs rarely become active at later differentiation stages.

Figure 3

(a) Chromatin state of enhancers primed in HSCs was investigated in Pro B, mature B cells, spleen and thymus. H3K4me1 and H3K27ac enrichments in the indicated cell types were calculated at genomic coordinates corresponding to primed enhancers in HSCs. Lines indicate cut-offs used to select enriched regions for each signal. The proportions of the different populations are indicated in the scatter plots. (b) Heatmap displaying enhancers primed in HSCs and clustered based on their H3K4me1 and H3K27ac enrichment in the indicated cell types and tissues. (c) Similar to A, the chromatin state of enhancers primed in Pro B cells was investigated in mature B cells.