Table 5.
Adjusted associations between pre-hospital vitamin D status and hospital-acquired new-onset delirium (HANOD)* (Odds ratios and 95 % confidence intervals, n 4508)
| Pre-hospital 25(OH)D |
||||
|---|---|---|---|---|
| <10 ng/ml | 10–199 ng/ml | 20–299 ng/ml | ≥30 ng/ml | |
| Adjusted+recent surgery | ||||
| OR | 2·13 | 1·51 | 1·21 | 1·00 |
| 95% CI | 1·30, 3·48 | 0·96, 2·39 | 0·75, 1·96 | Referent |
| P | 0·003 | 0·078 | 0·44 | |
| Adjusted+sepsis | ||||
| OR | 2·04 | 1·51 | 1·21 | 1·00 |
| 95% CI | 1·25, 3·33 | 0·96, 2·39 | 0·75, 1·96 | Referent |
| P | 0·004 | 0·076 | 0·43 | |
| Adjusted+ depression | ||||
| OR | 2·14 | 1·53 | 1·20 | 1·00 |
| 95% CI | 1·32, 3·48 | 0·97, 2·42 | 0·74, 1·94 | Referent |
| P | 0·002 | 0·067 | 0·45 | |
| Adjusted+ antipsychotics | ||||
| OR | 2·01 | 1·45 | 1·15 | 1·00 |
| 95% CI | 1·21, 3·35 | 0·91, 2·33 | 0·70, 1·90 | Referent |
| P | 0·007 | 0·12 | 0·57 | |
| Adjusted+leucocyte count | ||||
| OR | 2·15 | 1·52 | 1·23 | 1·00 |
| 95% CI | 1·32, 3·49 | 0·97, 2·41 | 0·76, 1·99 | Referent |
| P | 0·002 | 0·069 | 0·40 | |
| Adjusted+Ca | ||||
| OR | 2·15 | 1·55 | 1·24 | 1·00 |
| 95% CI | 1·33, 3·50 | 0·98, 2·44 | 0·77, 2·01 | Referent |
| P | 0·002 | 0·061 | 0·38 | |
| Adjusted+liver disease | ||||
| OR | 2·16 | 1·54 | 1·23 | 1·00 |
| 95% CI | 1·33, 3·51 | 0·98, 2·43 | 0·76, 1·99 | Referent |
| P | 0·002 | 0·063 | 0·39 | |
| Adjusted+season of 25(OH)D draw |
||||
| OR | 2·14 | 1·51 | 1·21 | 1·00 |
| 95% CI | 1·30, 3·49 | 0·96, 2·40 | 0·75, 1·96 | Referent |
| P | 0·003 | 0·076 | 0·43 | |
| Adjusted+timing of 25(OH)D draw | ||||
| OR | 2·09 | 1·52 | 1·23 | 1·00 |
| 95% CI | 1·28, 3·41 | 0·97, 2·40 | 0·76, 1·99 | Referent |
| P | 0·003 | 0·071 | 0·39 | |
| Adjusted+ICU admission | ||||
| OR | 2·22 | 1·61 | 1·23 | 1·00 |
| 95% CI | 1·36, 3·62 | 1·01, 2·55 | 0·76, 2·00 | Referent |
| P | 0·001 | 0·043 | 0·40 | |
25(OH)D, 25-hydroxyvitamin D; ICU, intensive care unit.
*
Adjusted associations between 25(OH)D groups and HANOD were estimated by multivariable logistic regression models with the inclusion of covariate terms considered to plausibly associate with both 25(OH)D concentrations and HANOD. Adjusted estimates adjusted for age, sex, race (non-white v. white), patient type (medical v. surgical) and Deyo–Charlson index.