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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: J Thorac Oncol. 2015 Nov;10(11):1648–1652. doi: 10.1097/JTO.0000000000000665

Figure 3.

Figure 3

Patients with split signals on ALK FISH had a median decrease in tumor diameter of 48% compared to patients with 5′ deletion on ALK FISH (38%; p=0.03). Of 11 patients with split signals, 8 had partial response, 3 had stable disease, and none had disease progression. Of 15 patients with 5′ deletion, 9 had partial response, 4 had stable disease, and 2 had disease progression, including one case with new liver metastases. Two of the 3 cases with discordant FISH and IHC results showed disease progression – both cases were negative for ALK rearrangement by NGS.