Figure 7.

Model for the suppression and activation of Rp1 proteins. Rp1 proteins form homo- and heteromers (Wang et al., 2015b). The inhibited state of Rp1 proteins (left) is maintained through autoinhibitory intramolecular interaction and interactions between HCT1806/HCT4918 and the CC domain. In the activated state (right), pathogen effectors modify HCT1806/HCT4918, disrupting the interaction between Rp1 proteins and HCT1806/HCT4918. This, in turn, disrupts the autoinhibitory intramolecular interactions; the interaction between the LRR and NB-ARC domains is strengthened, and the CC/NB-ARC interaction is weakened, leading to activation and HR. Blue and purple triangles indicate ADP and ATP, respectively. Arrows indicate intra- and intermolecular interactions. The putative pathogen effector is labeled with a red star. The rationale behind the models is explained in the text.