Table I. Summary of the state of knowledge of the cofactors and interaction domains of plant NLRs.

Abbreviations are as follows: Resistance to Pseudomonas syringae pv maculicola1 (RPM1), Resistance to Pseudomonas Syringae2 (RPS2), Suppressor of npr1-1, constitutive1 (SNC1), HopZ-Activated Resistance1 (ZAR1), Mildew A Locus10 (MLA10), Bacterial spot2 (Bs2), Panicle blast1 (Pb1), Constitutive expresser of PR genes1 (CPR1), basic Helix-loop-Helix84 (bHLH84), Enhanced disease susceptibility1 (EDS1), avrPphB susceptible1 (PBS1), HopZ-ETI-deficient1 (ZED1), Squamosa promoter binding protein-like6 (SPL6), suppressor of G2 allele of skp1 (SGT1), Ran GTPase activating protein2 (RanGAP2), and Bsu-like protein1 (BSL1). FL, Full length; TF, transcription factor; XNL, no typical CC or TIR domain was found in the N terminus; TNL, Toll-IL1 receptor-nucleotide binding LRR; —, no data available.

Host Species and Gene	Protein Type	Pathogen	Effector	Cofactors	Types of Cofactors	Interaction Domains with Cofactors	Source
Arabidopsis
RPM1	CNL	Pseudomonas syringae	AvrRpm1, AvrB	RIN4	Unknown	CC, FL	Mackey et al. (2002)
RPS2	CNL	P. syringae	AvrRpt2	RIN4	Unknown	CC, FL	Axtell and Staskawicz (2003); Mackey et al. (2003)
				CPR1	F-box	FL	Cheng et al. (2011)
RPS4	TNL	P. syringae	AvrRps4	bHLH84	TF	FL	Xu et al. (2014)
				EDS1	Lipase-like	FL	Bhattacharjee et al. (2011); Heidrich et al. (2011)
RPS5	CNL	Peronospora parasitica	AvrPphB	PBS1	Kinase	CC, FL	Ade et al. (2007)
RPS6	TNL	P. syringae	AvrHopA1	EDS1	Lipase-like	FL	Bhattacharjee et al. (2011)
SNC1	TNL	P. syringae	—	bHLH84	TF	FL	Xu et al. (2014)
				CPR1	F-box	FL	Cheng et al. (2011)
				EDS1	Lipase-like	FL	Bhattacharjee et al. (2011)
ZAR1	CNL	P. syringae	AvrHopZ1a	ZED1	Pseudokinase	CC, FL	Lewis et al. (2013)
Barley
MLA10	CNL	Blumeria graminis	AvrA10	WRKY1, WRKY2	TF	CC, FL	Shen et al. (2007)
				MYB6	TF	CC, FL	Chang et al. (2013)
Maize
Rp1-D	CNL	P. sorghi	—	HCT homologs	Lignin biosynthesis	FL	This study; Wang et al. (2015b)
Rp1-dp2	CNL	—	—	HCT homologs	Lignin biosynthesis	CC, FL	This study; Wang et al. (2015b)
Rp1-D21	CNL	—	—	HCT homologs	Lignin biosynthesis	CC, FL	This study; Wang et al. (2015b)
Nicotiana tabacum
N	TNL	Tobacco mosaic virus	P50	SPL6	TF	TIR, LRR, FL	Padmanabhan et al. (2013)
Pepper (Capsicum annuum)
Bs2	XNL	Xanthomonas campestris pv vesicatoria	AvrBs2	SGT1	Molecular cochaperone	LRR, FL	Leister et al. (2005)
Potato (Solanum tuberosum)
Rx	CNL	Potato virus X	Coat protein	RanGAP2	Small GTPase	CC, FL	Tameling and Baulcombe (2007)
R2	CNL	Phytophthora infestans	AVR2	BSL1	Phosphatase	FL	Saunders et al. (2012)
Rice
Pb1	CNL	Magnaporthe oryzae	—	WRKY45	TF	CC, FL	Inoue et al. (2013)
Pit	CNL	M. oryzae	—	Rac1	Small GTPase	NB-ARC, FL	Kawano et al. (2010)
Tomato (Solanum lycopersicum)
Prf	XNL	P. syringae	AvrPto, AvrPtoB	Pto	Kinase	CC, FL	Mucyn et al. (2006)