Fig. 6.

Predicted Secondary Structure Matching of Agenet/Tudor domain from AIP1 with different Tudor domains. a Alignment of secondary structures performed by ProFunc using Agenet/Tudor sequence from AIP1 as query. The proteins shown are: 1. PHF1 Tudor in complex with H3K36me3 by X-Ray Diffraction; 2. Crystal structure of Tudor domain 2 of human PHF20 by X-Ray Diffraction; 3. Tudor domain of human TDRD3 (Tudor domain- protein 3) by X-Ray Diffraction; 4. Solution NMR (Nuclear Magnetic Resonance) for human PHF19 linking H3K36me; 5. Tudor domain of human TDRD3 by X-Ray Diffraction; 6. Human Tudor domain of SMN1 in complex with aa organic molecule by X-Ray Diffraction; 7. Human TDRD3 complex with asymmetric dimethylarginine mark in histone by Solution NMR; 8. Solution NMR structure of the human Tudor domain of PHF19, isoform b; 9. The second Tudor domain of human PHF20 by X-Ray Diffraction. b Modeled structure of the Agenet/Tudor domain of AIP1 (Green) superimposed to the Tudor domain of PHF1 (Hit 1. PDB id: 4HCZ) (Red)