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. 2012 Nov 30;7(6):1158–1167. doi: 10.1111/irv.12058

Figure 2.

Figure 2

 ALL chemotherapy has a cumulative effect on B‐cell function. The ALL group was divided into three cohorts depending on the stage of chemotherapy at the time of vaccination. We identified differences between the three cohorts using the Kruskal–Wallis test. The cohort vaccinated during induction had more robust responses to each serotype (A). We examined total IgG production after stimulation (B) in an ELISPOT analysis and found that the three cohorts differed at baseline (P = 0·0001). We examined influenza antibody production in an ELISPOT analysis (C) and found that there were significant differences at baseline and the 2‐month time point (P < 0·0001 and P = 0·0111, respectively). Asterisks indicate significance.