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. 2012 Nov 30;7(6):1158–1167. doi: 10.1111/irv.12058

Figure 3.

Figure 3

 B‐cell subsets differ between the three ALL cohorts. The ALL group was divided into three cohorts depending on the stage of chemotherapy on the day of vaccination. We assessed B‐cell subset counts using flow cytometry and compared the subset counts using the Kruskal–Wallis test. The asterisks indicate statistical significance. Total B‐cell counts (CD19+) differed between cohorts on the day of vaccination and the 1‐year time point (P = 0·0002, P = 0·0035). Similarly, naïve B cells differed at those two points (P = 0·0002 and P = 0·0038) and non‐switched memory B cells differed at the same two time points (P < 0·0001 and P = 0·0065). Switched memory B cells differed at baseline, the 2‐month and 1‐year time points (P = 0·0002, P = 0·0250, and P = 0·0150). The children on maintenance chemotherapy on the day of vaccination demonstrate some recovery in their B‐cell counts at the 1‐year time point.