Figure 4.

 B‐cell subsets differ between the three solid tumor cohorts. The solid tumor group was divided into three cohorts depending on the length of time they had been on chemotherapy on the day they were vaccinated. We used the Kruskal–Wallis test to identify time points where the three cohorts differed significantly. The asterisks indicate statistical differences. There were differences between the three cohorts at baseline and the 1‐year time point as was true in the ALL cohorts and again there was improvement for those subjects off chemotherapy at the 1‐year time point. The differences at baseline are significant for all four subsets with total, naïve, non‐switched memory, and switched memory P values of <0·0001, 0·0007, <0·0001, and 0·00005, respectively. The 1‐year time points were significantly different for total, naïve, non‐switched memory, and switched memory B cells with P values of 0·0009, 0·0011, 0·0011, and 0·0026, respectively.