Table 1.
Characteristics of the eligible studies considered in the meta-analysis.
| Study ID | Country | Ethnicity | Case/control | Control source | Genotyping method | HWE | Study quality |
|---|---|---|---|---|---|---|---|
| Sharp et al. (2002) | UK | Caucasian | 54/57 | PB | PCR-RFLP | 0.10 | 4 |
| Campbell et al. (2002) | Australia | Caucasian | 335/233 | HB | PCR-RFLP | 0.41 | 6.5 |
| Semenza et al. (2003) | USA | Caucasian | 105/247 | HB | PCR-RFLP | 0.64 | 6 |
| Langsenlehner et al. (2003) | Austria | Caucasian | 494/495 | PB | PCR-RFLP | 0.33 | 7 |
| Ergul et al. (2003) | Turkey | Caucasian | 118/193 | HB | PCR-RFLP | 0.16 | 6.5 |
| Shrubsole et al. (2004) | China | Asian | 1112/1160 | PB | PCR-RFLP | 0.44 | 8.5 |
| Forsti et al. (2004) | Poland | Caucasian | 223/298 | NR⁎ | PCR-RFLP | 0.68 | 7 |
| Lee et al. (2004) | Australia | Caucasian | 186/147 | HB | PCR-RFLP | 0.07 | 7.5 |
| Grieu et al. (2004) | Korea | Asian | 334/551 | PB | PCR-RFLP | 0.10 | 7 |
| Lin et al. (2004) | Taiwan | Asian | 88/342 | PB | PCR-RFLP | 0.38 | 7 |
| Le Marchand et al. (2004) | Hawaiian | Caucasian | 1189/2414 | PB | TaqMan | 0.75 | 8.5 |
| Qi et al. (2004) | China | Asian | 217/218 | PB | PCR-RFLP | 0.59 | 4.5 |
| Chen et al. (2005) | USA | Caucasian | 1063/1104 | PB | PCR-RFLP | 0.68 | 9.5 |
| Kalemi et al. (2005) | Greece | Caucasian | 42/51 | NR⁎ | PCR-RFLP | 0.31 | 5 |
| Deligezer et al. (2005) | Turkey | Caucasian | 189/223 | NR⁎ | PCR-RFLP | 0.75 | 7 |
| Justenhoven et al. (2005) | Germany | Caucasian | 557/633 | PB | MALDI-TOF | 0.19 | 8 |
| Chou et al. (2006) | China | Asian | 142/285 | HB | PCR-RFLP | 0.47 | 7 |
| Kalyankumar and Jamil (2006) | India | Asian | 88/95 | HB | PCR-RFLP | 0.69 | 6.5 |
| Xu et al. (2007) | USA | Caucasian | 1063/1104 | PB | PCR-RFLP | 0.68 | 8.5 |
| Hekim et al. (2007) | Turkey | Caucasian | 40/68 | NR⁎ | PCR-RFLP | 0.87 | 6 |
| Kan et al. (2007) | China | Asian | 125/103 | PB | PCR-RFLP | 0.04 | 7 |
| Lissowska et al. (2007) | Poland | Caucasian | 1974/2282 | PB | TaqMan | 0.01 | 8 |
| Macis et al. (2007) | Italy | Caucasian | 46/80 | PB | TaqMan | 0.51 | 4 |
| Reljic et al. (2007) | Croatia | Caucasian | 93/65 | PB | PCR-RFLP | 0.11 | 6 |
| Stevens et al. (2007) | USA | Others | 494/494 | PB | TaqMan | 0.01 | 7 |
| Yu et al. (2007) | Taiwan | Asian | 119/420 | PB | PCR-RFLP | 0.33 | 7.5 |
| Inoue et al. (2008) | Singapore | Asian | 380/662 | PB | TaqMan | 0.17 | 9 |
| Kotsopoulos et al. (2008) | Canada | Caucasian | 944/680 | HB | Mass-array system | 0.08 | 7.5 |
| Suzuki et al. (2008) | Japan | Asian | 454/909 | HB | TaqMan | 0.52 | 9.5 |
| Cheng et al. (2008) | Taiwan | Asian | 349/530 | HB | PCR-RFLP | 0.62 | 6.5 |
| Langsenlehner et al. (2008) | Austria | Caucasian | 105/105 | NR⁎ | PCR-RFLP | 0.68 | 6 |
| Mir et al. (2008) | India | Asian | 35/33 | HB | PCR-RFLP | 0.95 | 4 |
| Ericson et al. (2009) | Sweden | Caucasian | 540/1074 | PB | MALDI-TOF | 0.70 | 6 |
| Gao et al. (2009) | China | Asian | 624/624 | PB | PCR-RFLP | 0.59 | 9 |
| Ma et al. (2009) | Japan | Asian | 388/387 | HB | TaqMan | 0.66 | 6.5 |
| Platek et al. (2009) | USA | Caucasian | 994/1802 | PB | TaqMan | 0.39 | 9 |
| Hennquez-Hernandez et al. (2009) | Spain | Caucasian | 135/292 | PB | PCR-RFLP | 0.82 | 7 |
| Cam et al. (2009) | Turkey | Caucasian | 110/95 | NR⁎ | PCR-RFLP | 0.39 | 4.5 |
| Maruti et al. (2009) | USA | Caucasian | 318/647 | PB | ASPE | 0.67 | 8.5 |
| Ma et al. (2009) | Brazil | Others | 458/458 | HB | NR⁎ | 0.30 | 8.5 |
| Li et al. (2009) | China | Asian | 65/143 | PB | PCR-RFLP | 0.18 | 7 |
| Yuan et al. (2009) | China | Asian | 80/80 | HB | PCR-RFLP | 0.51 | 6.5 |
| Jin et al. (2009) | China | Asian | 41/100 | NR⁎ | PCR-RFLP | 0.74 | 7.5 |
| Bentley et al. (2010) | USA | Caucasian | 939/1163 | HB | PCR-RFLP | 0.05 | 8 |
| Alshatwi (2010) | Arab | Asian | 100/100 | HB | TaqMan | 0.80 | 6.5 |
| Sangrajrang et al. (2010) | Indian | Asian | 563/487 | HB | TaqMan | 0.42 | 9 |
| Weiner et al. (2010) | Russia | Asian | 837/778 | PB | PCR-RFLP | 0.80 | 8 |
| Wu et al. (2010) | China | Asian | 80/80 | HB | PCR-RFLP | 0.51 | 5.5 |
| Batschauer et al. (2011) | Brazil | Others | 68/85 | PB | PCR-RFLP | 0.59 | 4.5 |
| Cerne et al. (2011) | Caucasian | Caucasian | 522/269 | PB | Sequencing | 0.88 | 6 |
| Hosseini et al. (2011) | Iran | Asian | 294/300 | HB | PCR-RFLP | < 0.0001 | 3 |
| Hua et al. (2011) | China | Asian | 95/90 | PB | PCR-RFLP | 0.02 | 6.5 |
| Nausad et al. (2011) | India | Asian | 244/244 | HB | PCR-RFLP | 0.17 | 7 |
| Prasad et al. (2011) | India | Asian | 130/125 | PB | PCR-RFLP | 0.06 | 6 |
| Akram et al. (2012) | Pakistan | Asian | 110/110 | HB | PCR-RFLP | 0.85 | 5 |
| Barbosa et al. (2012) | Mixed, Caucasian | Caucasian | 176/176 | HB | PCR-RFLP | 0.38 | 5.5 |
| Diakite et al. (2012) | Morocco | Others | 96/117 | HB | PCR-RFLP | 0.78 | 7 |
| Jakubowska et al. (2012) | Mixed, Caucasian | Caucasian | 4778/3350 | PB | TaqMan | 0.15 | 7 |
| Lajin et al. (2012) | Syria | Asian | 119/126 | HB | PCR-RFLP | 0.35 | 6.5 |
| Wu et al. (2012) | China | Asian | 32/37 | NR⁎ | PCR-RFLP | 0.03 | 6 |
| Liu et al. (2013) | China | Asian | 435/435 | HB | PCR-RFLP | 0.57 | 6 |
| Ozen et al. (2013) | Turkey | Caucasian | 51/106 | NR⁎ | Strip-assay | 0.08 | 4 |
| He et al. (2014) | China | Asian | 310/381 | HB | Sequenom | < 0.0001 | 6 |
| Huang et al. (2014) | Taiwan | Asian | 1232/1232 | HB | PCR-RFLP | 0.01 | 8 |
| Jiang-hua et al. (2014) | China | Asian | 535/673 | HB | PCR-RFLP | < 0.0001 | 7 |
| Wang et al. (2014) | China | Asian | 435/435 | HB | Sequenom | 0.22 | 6 |
| Weiwei et al. (2014) | China | Asian | 297/306 | HB | Sequenom | 0.00 | 8 |
| Kakkoura et al. (2015) | Cyprus | Caucasian | 1065/1157 | PB | TaqMan | 0.09 | 9.5 |
| Lopez-Cortes et al. (2015) | Ecuador | Others | 114/195 | HB | PCR-RFLP | 0.00 | 7 |
| Lu et al. (2015) | China | Asian | 560/560 | HB | TaqMan | 0.27 | 9 |
| Singh et al. (2015) | India | Asian | 588/508 | HB | PCR-RFLP | 0.37 | 5.5 |
⁎
NR = not reported.