Table 2.
Genetic contrast | Fixed effect OR (95% CI), p |
Random effect OR (95% CI), p |
Heterogeneity p-value (Q test) | I2 (%) | |
---|---|---|---|---|---|
All (75 studies) |
Allele contrast (T vs. C) | 1.05 (1.02–1.07), < 0.001 | 1.08 (1.03–1.13), < 0.001 | < 0.001 | 63 |
Dominant (TT + CT vs. CC) | 1.06 (1.02–1.09), < 0.001 | 1.08 (1.03–1.14), 0.002 | < 0.001 | 48 | |
Homozygote (TT vs. CC) | 1.10 (1.04–1.16), < 0.001 | 1.17 (1.06–1.28), 0.001 | < 0.001 | 60 | |
Co-dominant (CT vs. CC) | 1.05 (1.01–1.08), 0.005 | 1.05 (1.01–1.10), 0.01 | 0.01 | 29 | |
Recessive (CC + CT vs. TT) | 1.07 (1.02–1.13), 0.002 | 1.12 (1.03–1.22), 0.005 | < 0.001 | 55 | |
Ethnicity | |||||
Asian (37 studies) |
Allele contrast (T vs. C) | 1.06 (1.02–1.11), < 0.001 | 1.11 (1.02–1.21), 0.01 | < 0.001 | 75 |
Dominant (TT + CT vs. CC) | 1.07 (1.01–1.12), 0.009 | 1.10 (1.00–1.20), 0.04 | < 0.001 | 64 | |
Homozygote (TT vs. CC) | 1.15 (1.06–1.25), < 0.001 | 1.26 (1.06–1.51), 0.009 | < 0.001 | 71 | |
Co-dominant (CT vs. CC) | 1.04 (0.99–1.10), 0.08 | 1.05 (0.97–1.14), 0.19 | 0.003 | 43 | |
Recessive (CC + CT vs. TT) | 1.12 (1.04–1.21), 0.003 | 1.21 (1.04–1.40), 0.01 | < 0.001 | 65 | |
Caucasian (31 studies) |
Allele contrast (T vs. C) | 1.03 (1.00–1.06), 0.02 | 1.04 (1.00–1.09), 0.04 | 0.04 | 32 |
Dominant (TT + CT vs. CC) | 1.04 (1.00–1.08), 0.05 | 1.04 (1.00–1.08), 0.05 | 0.56 | 0 | |
Homozygote (TT vs. CC) | 1.06 (0.99–1.14), 0.05 | 1.08 (0.97–1.21), 0.12 | 0.007 | 43 | |
Co-dominant (CT vs. CC) | 1.03 (0.99–1.08), 0.12 | 1.03 (0.99–1.08), 0.12 | 0.79 | 0 | |
Recessive (CC + CT vs. TT) | 1.05 (0.99–1.12), 0.09 | 1.07 (0.96–1.19), 0.18 | 0.002 | 47 | |
Others (7 studies) |
Allele contrast (T vs. C) | 1.10 (0.99–1.21), 0.05 | 1.12 (0.97–1.28), 0.09 | 0.11 | 41 |
Dominant (TT + CT vs. CC) | 1.17 (1.02–1.33), 0.01 | 1.23 (0.99–1.53), 0.05 | 0.03 | 57 | |
Homozygote (TT vs. CC) | 1.14 (0.91–1.42), 0.23 | 1.14 (0.91–1.44), 0.22 | 0.40 | 2 | |
Co-dominant (CT vs. CC) | 1.19 (1.03–1.36), 0.01 | 1.24 (1.00–1.55), 0.04 | 0.03 | 55 | |
Recessive (CC + CT vs. TT) | 1.03 (0.84–1.26), 0.74 | 1.03 (0.84–1.27), 0.73 | 0.77 | 0 | |
Study design | |||||
Hospital based (34 studies) |
Allele contrast (T vs. C) | 1.07 (1.03–1.12), < 0.001 | 1.14 (1.05–1.23), < 0.001 | < 0.001 | 73 |
Dominant (TT + CT vs. CC) | 1.08 (1.03–1.14), 0.001 | 1.14 (1.04–1.26), 0.004 | < 0.001 | 65 | |
Homozygote (TT vs. CC) | 1.15 (1.06–1.25), < 0.001 | 1.27 (1.08–1.50), 0.003 | < 0.001 | 69 | |
Co-dominant (CT vs. CC) | 1.06 (1.01–1.12), 0.02 | 1.10 (1.01–1.20), 0.02 | < 0.001 | 54 | |
Recessive (CC + CT vs. TT) | 1.12 (1.04–1.21), 0.002 | 1.20 (1.05–1.39), 0.008 | < 0.001 | 63 | |
Population based (32 studies) |
Allele contrast (T vs. C) | 1.03 (1.00–1.06), 0.04 | 1.03 (0.98–1.09), 0.15 | 0.001 | 48 |
Dominant (TT + CT vs. CC) | 1.04 (0.99–1.08), 0.05 | 1.04 (0.98–1.09), 0.12 | 0.13 | 22 | |
Homozygote (TT vs. CC) | 1.06 (0.99–1.13), 0.07 | 1.08 (0.96–1.21), 0.16 | < 0.001 | 50 | |
Co-dominant (CT vs. CC) | 1.03 (0.99–1.08), 0.10 | 1.03 (0.99–1.08), 0.10 | 0.61 | 0 | |
Recessive (CC + CT vs. TT) | 1.04 (0.97–1.10), 0.20 | 1.05 (0.95–1.16), 0.27 | 0.003 | 45 | |
Menopausal status | |||||
Pre-menopausal (9 studies) |
Allele contrast (T vs. C) | 1.01 (0.90–1.12), 0.84 | 1.01 (0.98–1.12), 0.84 | 0.68 | 0 |
Dominant (TT + CT vs. CC) | 1.00 (0.87–1.17), 0.90 | 1.00 (0.86–1.16), 0.92 | 0.45 | 0 | |
Homozygote (TT vs. CC) | 1.01 (0.80–1.28), 0.89 | 1.01 (0.80–1.28), 0.89 | 0.63 | 0 | |
Co-dominant (CT vs. CC) | 1.00 (0.85–1.17), 0.99 | 1.01 (0.84–1.21), 0.88 | 0.25 | 20 | |
Recessive (CC + CT vs. TT) | 1.02 (0.82–1.27), 0.83 | 1.02 (0.81–1.27), 0.84 | 0.50 | 0 | |
Post-menopausal (9 studies) |
Allele contrast (T vs. C) | 1.03 (0.95–1.12), 0.40 | 1.05 (0.92–1.20), 0.39 | 0.03 | 51 |
Dominant (TT + CT vs. CC) | 1.08 (0.96–1.20), 0.16 | 1.09 (0.95–1.25), 0.20 | 0.22 | 24 | |
Homozygote (TT vs. CC) | 1.01 (0.85–1.20), 0.87 | 1.06 (0.77–1.45), 0.71 | 0.01 | 57 | |
Co-dominant (CT vs. CC) | 1.10 (0.98–1.23), 0.10 | 1.10 (0.98–1.23), 0.10 | 0.62 | 0 | |
Recessive (CC + CT vs. TT) | 0.96 (0.82–1.13), 0.68 | 0.99 (0.75–1.30), 0.96 | 0.04 | 48 |