Fig. 2.
Intracortical inhibition determined by dp-TMS. (A) Task-related paradigm. Based on individual reaction times (RT) during the preparation of a simple finger abduction movement, determined before the TMS experiment, unconditioned and conditioned dp-TMS pulses were applied randomly at early (~ 20%) or at late (~ 90%) phase of the individual RT. (B) SICImov modulation after day-1 training. There was a training specific modulation of inhibition (towards disinhibition) present in healthy subjects (green solid line) close to the movement onset compared to baseline measurements (dashed line), a pattern that was absent in NF1 patients. (C) Compared to healthy participants, there was a reduction of Δ SICI modulation in NF1 after training (gray line: single subject data; purple line: group average). As a result of that, (D) a significantly greater SICImov modulation (ratio Day1/Base) in healthy participants compared to NF1 patients has been observed, mainly driven by enhanced task-related disinhibition after training in healthy participants. Data show mean ± SEM, * indicates p < 0.05.