Fig. 8.

Overview of how the HGCC biobank will support translational brain tumor research. We provide a large-scale, open access repository of patient-derived GBM cell cultures matched with clinical data (A) that enables accurate cell-based modeling of GBM diversity. Coupled to the cell bank we make available a user-friendly data repository (B) to support users in their selection of HGCC lines with particular properties, molecular subtype or marker expression. We foresee a multitude of applications (C), such as single/oligo cell line studies of e.g. candidate genes and mechanisms in vitro and in vivo (xenograft modeling), multi-cell line studies, e.g. screening for inhibitory compounds or siRNAs, and data mining in relation to other publically available data sets.