Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Sep 16;24(23):6640–6652. doi: 10.1093/hmg/ddv369

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author 2015. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 3. — Skeletal and biochemical indices of GCase deficiency. At 12 wpf gba1^−/− (A) developed a curve to their spine compared with wild-type (WT) controls (B) in a similar manner to some conditional GBA1 KO mice (17). The difference in the stripe pattern of gba1^−/− (A) and wild-type zebrafish (B) is due to the gba1^+/− line being of mixed lineage with (wild-type) AB and (wild-type) TL genetic background. Classical Gaucher disease biomarkers were markedly elevated in gba1^−/− brains at 12 wpf, with a 10-fold increase in chitotriosidase activity (P < 0.0001) (C) and a 4-fold increase in β-hexosaminidase activity (P < 0.0001) (D). No significant changes were detected in either assay in gba1^+/− brains. ****P <0.0001.