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. 2015 Sep 16;24(23):6640–6652. doi: 10.1093/hmg/ddv369

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© The Author 2015. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Activation of inflammatory/immune mechanisms during larval stages. Microglia in 4 dpf gba1^+/− and gba1^−/− had an increase in shape factor (sphericity) (P < 0.001 for both) indicative of microglial activation (A). Additionally, the number of vacuoles in gba1^−/− was increased by 40% compared with the values observed in wild-type (WT) controls (P < 0.0001) (B). Levels of miR-155, a master regulator of inflammatory/immune mechanisms, were analyzed in 5 dpf larvae (C) and 12 wpf brain tissue (D) across gba1 genotypes. miR-155 was increased 2-fold in gba1^−/− larvae (P < 0.05) and 4-fold in 12 wpf gba1^−/− brains (P < 0.01). *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.