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. 2015 Sep 16;24(23):6640–6652. doi: 10.1093/hmg/ddv369

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© The Author 2015. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Mitochondrial dysfunction and autophagy in gba1^−/− zebrafish. There was a 50% decrease (P < 0.05) in complex III (A) and complex IV (B) activity in gba1^−/− brains at 12 wpf. There was also a decrease in the protein levels of the complex I subunit NDUFA9 (C, P < 0.01) and the complex IV subunit Cox4i1 (D, P < 0.01). LC3-II was increased 2-fold in gba1^−/− brains at 12 wpf compared with wild-type (WT) (E, P < 0.01). (F) A representative western blot of LC3-II protein levels in wild-type and gba1^−/− zebrafish brains. *P < 0.05; **P < 0.01.