Figure 4.
(a) Temperature change profiles during laser irradiation for Croc/DOX/LP-hybrid-NP (orange), ICG/DOX/LP-hybrid-NP (dark green), and IR780/DOX/LP-hybrid-NP (light green) at pH 7.4 (HEPES buffer). Control experiment: LP-hybrid-NPs without any dye at pH 7.4 (HEPES buffer) (grey) and HEPES buffer alone at pH 7.4 (black). (b-d) DOX fluorescence (λex = 480 nm) in samples of Croc/DOX/LP-hybrid-NP, ICG/DOX/LP-hybrid-NP, and IR780/DOX/LP-hybrid-NP, respectively, before (black) and after (red) laser (15 min) irradiation. The DOX decrease in the three samples was 4%, 30% and 35%, respectively.