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. 2015 Nov 4;12:203. doi: 10.1186/s12974-015-0411-8

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© Cherry et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Aβ is taken up by Arg1+ microglia. a Representative confocal images of Arg1+ cell (green) containing Aβ (red) after rAAV2-IL1β injection. DAPI (blue) is used as to counter stain cell nuclei. Scale bars represent 10 μm. b Quantification of iNOS+ or Arg1+ microglia in the hippocampus that contain Aβ after 4 weeks rAAV2-Phe or rAAV2-IL1β injection. Data displayed as mean ± SEM, n = 5 animals, ***p < 0.0001, ****p < 0.00001. c Representative images of Arg1+ or iNOS+ microglia containing 6E10 inside the lysosome (Lamp1). Scale bars represent 10 μm