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Treatment of age‐related hepatic ischemia/reperfusion injury in mice
| Findings in liver cells | Children (4–5 weeks) | Young adults (10–12 weeks) | Older adults (9–12 months) |
|---|---|---|---|
| PPARγ activity | ++ | + | ± |
| PPARγ– nuclear | ++ | – | – |
| PPARγ– cytoplasm | – | + | ++ |
| Autophagy | ++ | + | – |
| Rosiglitazone effect on autophagy | nd | ++ | nd |
Adapted from Ref. (119).
PPAR, peroxisome proliferator activator receptor; nd, not done.
