Table 1.
BRCA screening by ethnicity
| West Eur | Cent Eur | Latin Am | African | Asian | Nat Am | Mid East | All | |
|---|---|---|---|---|---|---|---|---|
| BRCA1 | 2501 | 336 | 185 | 180 | 75 | 44 | 30 | 3351 |
| BRCA2 | 1899 | 214 | 105 | 100 | 75 | 35 | 16 | 2444 |
| Total mutant | 4400 | 550 | 290 | 280 | 150 | 79 | 46 | 5795 |
| Subjects | 36235 | 4066 | 1936 | 1767 | 1183 | 597 | 492 | 46276 |
| % Mutation | 12 % | 14 % | 15 % | 16 % | 13 % | 13 % | 9 % | 13 % |
| Ratio BRCA1/2 | 1.32 | 1.57 | 1.76 | 1.80 | 1.00 | 1.26 | 1.88 | 1.37 |
| % Sample | 78 % | 9 % | 4 % | 4 % | 3 % | 1 % | 1 % | |
| US pop (1000s) | 196817 | 50477 | 37686 | 14465 | 2247 | |||
| Screened/100,000 | 18.4 | 3.84 | 4.69 | 8.18 | ||||
| Ratio West Eur/minority | 4.80 | 3.93 | 2.25 | |||||
Data from Hall et al. [17] on BRCA screening and mutations identified by ethnic group were used to calculate the ratio of BRCA1/BRCA2 mutations (ratio BRCA1/2), and the percentage of the total sample represented by that ethnicity (% sample). The size of selected ethnic groups according to the US Census in thousands (US Pop (1000s)) divided by the number of subjects yields the number screened per 100,000 (Screened/100,000). The ratio of Western Europeans (West Eur) screened to Latin Americans (Latin Am), African Americans (African), and Asian American (Asians) was calculated by dividing Screened/100,000 for West Eur (18.4) by the corresponding figure of the minority population (Ratio West Eur/minority). Including the Central European (Cent Eur) women in with the West Eur women raises the minority ratios slightly (not shown)