Table 3.
The list of transcription factors removed by standard NCA algorithm but retained by ISNCA in the HRG data set and its involvement in previous breast cancer studies
| TF symbol | Description | Breast cancer related? | % removed | PMIDs |
|---|---|---|---|---|
| ATF2 | Activating transcription factor 2 | Yes | 81 | 19331149, 18677098, |
| 17079470, 17258390 | ||||
| FOXA1 | Forkhead box A1 | Yes | 85 | 19261198, 24528009, |
| 25155268, 17373880 | ||||
| SMAD5 | SMAD family member 5 | Yes | 86 | 23334326, 19096363 |
| 17786313 | ||||
| RARG | Retinoic acid receptor-gamma | Yes | 81 | 21482774, 15375546 |
| 10928067 | ||||
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | Yes | 71 | 21482774, 15375546 |
| E2F2 | E2F transcription factor 2 | Yes | 92 | 25028721, 24934442, |
| 24362522 | ||||
| NFkB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 | Yes | 89 | 12835724, 7478612 |
| TCF7 | transcription factor 7 | Yes | 91 | 26079538, 24401947 |
| SP2 | Sp2 transcription factor | Yes | 93 | 20382698 |
| PAX6 | Paired box 6 | Yes | 86 | 21944253, 25323813 |
| PGR | Progesterone receptor | Yes | 91 | 26277479, 26153859 |
% removed indicates that number of times standard NCA failed to retain the particular transcription factor on 100 tested networks. PMID is the PubMed database identification number