Table 3.

Top pathway results from GATHER analysis

Term ID	Term	p-value
hsa04520	Adherens junction	0.00149
hsa00590	Prostaglandin and leukotriene metabolism	0.00775
hsa04350	TGF-beta signaling pathway	0.0132
hsa04510	Focal adhesion	0.014

For genes that exhibited consistent fold-change directions in the Utah and Ontario gene-expression data (Additional files 7 and 8), we sorted the genes by average rank of fold change and t-test p-values. The 250 top-ranked genes were used to query GATHER [39] for KEGG pathways most strongly associated with this gene list. Pathways that attained a p-value less than 0.05 are shown