Fig 8. Upstream regulators involved during early folliculogenesis.

This Figure focuses on four upstream regulators of interest predicted to be activated or inhibited at key transitions during follicular development. Genes in our dataset are highlighted based on up- (green) or down- (red) expression and increasing intensity in line with the degree of fold change. The predicted action of the central gene is indicated as activated (orange) or inhibited (blue) with the degree of confidence increasing in line with color intensity. Arrowheads at the ends of the interactions indicate activation, whereas bars indicate inhibitory effects. Unbroken arrows and dashed arrows represent direct and indirect interactions between genes and upstream regulators, respectively. Predicted activation of (A) NOBOX in oocytes at small antrum stage, (B) KITL in granulosa cells at small antrum stage, (C) KLF9 in oocytes at small antrum stage, (D) BMPER in oocytes at secondary stage.